Erectile dysfunction (ED) affects millions of men worldwide, and with various treatment options available, choosing the right medication can be confusing. Two of the most well-known ED treatments are Cialis (tadalafil) and Viagra (sildenafil), both of which are effective in improving erectile function. However, one of the key differences between them is how long they last in the body.
At onlinemeds, we help patients find the most suitable treatment for their lifestyle and needs. If you’re wondering whether Cialis or Viagra lasts longer, this guide will explain their duration of action, effectiveness, and how to choose the right one for you.
How Do Cialis and Viagra Work?
Both Cialis and Viagra belong to a class of drugs known as PDE5 inhibitors. They work by relaxing the blood vessels in the penis, allowing for improved blood flow when sexually stimulated. However, they differ in their chemical composition, which affects how long they work and how quickly they take effect.
How Long Does Viagra Last?
Viagra, or its generic form sildenafil, typically lasts for about 4 to 6 hours. While the effects may start within 30 to 60 minutes of taking the tablet, peak effectiveness usually occurs after one hour.
Viagra works best on an empty stomach, as food (especially high-fat meals) can delay absorption. It remains active for up to 6 hours, though the effects gradually weaken over time. This means that use requires timing – you need to plan when to take it before sexual activity.
Because Viagra has a shorter duration, it is often suitable for men who prefer on-demand treatment rather than a longer-lasting effect.
How Long Does Cialis Last?
Cialis, or its generic version tadalafil, is well known for its long duration of action. Unlike Viagra, Cialis can remain effective for up to 36 hours, earning it the nickname “the weekend pill”.
It takes 30 to 60 minutes to work, but can remain active in the body for over a day and a half. This allows for greater spontaneity, as there is no need to take it right before sexual activity. In addition, it can be taken as a daily low-dose tablet (2.5mg or 5mg) for continuous effectiveness.
Because of its extended duration, Cialis is often preferred by men who want flexibility in their sex life without having to plan around taking medication.
Cialis vs Viagra: Which One Lasts Longer?
When comparing Cialis vs Viagra, Cialis clearly lasts significantly longer. While Viagra is effective for a few hours, Cialis offers an extended window of opportunity, which can be beneficial for men who prefer not to schedule intimacy.
Viagra (sildenafil)
–> Lasts 4 to 6 hours
–> Best for one-time use
–> Requires planning around meals and timing
Cialis (tadalafil)
–> Lasts up to 36 hours
–> Allows for spontaneous intimacy
–> Available as a daily low-dose option
For men who only need occasional help with erections, Viagra may be sufficient. However, for those who want a more natural experience without needing to take a pill each time, Cialis is often the better option.
Does the Duration of the Medication Affect Side Effects?
Both Cialis and Viagra have similar side effects, including headaches, flushing, nasal congestion, and indigestion. However, because Cialis stays in the body much longer, some men may experience side effects for an extended period compared to Viagra.
Other factors to consider include:
Viagra is affected by food – Eating a heavy meal before taking Viagra can delay its effectiveness, while Cialis is less affected by food intake.
Cialis has a longer half-life – This means it remains in the bloodstream longer, which may be beneficial for some but could cause prolonged side effects for others.
Daily Cialis may cause fewer fluctuations – Some men prefer the low-dose daily Cialis option, as it provides a steady level of the medication without the peaks and troughs seen with on-demand use.
Which One Is Right for You?
Choosing between Cialis and Viagra depends on your lifestyle, preferences, and how frequently you need ED treatment.
Cialis may be better if:
–> You want a longer-lasting medication with less need for planning.
–> You prefer the option of a daily low-dose tablet for continuous effectiveness.
–> You experience performance anxiety and want to reduce the pressure of timing the medication.
Viagra may be better if:
–> You only need occasional help with erections.
–> You prefer a medication that leaves the system faster.
–> You do not experience side effects and are comfortable taking it before planned intimacy.
It is important to buy both medications through a reputable pharmacy, and ensure that they are safe to take with other medications you may be on. Contact us to discuss this further.
The Bottom Line
When comparing Cialis vs Viagra, Cialis clearly has the advantage in terms of duration, lasting up to 36 hours compared to Viagra’s 4 to 6 hours. However, both medications are highly effective, and the best choice depends on personal preference and lifestyle.
If you’re unsure which is right for you, speak to one of our online healthcare professionals at onlinemeds to find the most suitable ED treatment for your needs.

Written by Gavin Cheema, Superintendent Pharmacist. GPhC Number: 2214516
With over eight years of experience in community, hospital, and online pharmacies, Gavin is a highly skilled Clinical Pharmacist and expert in UK pharmacy regulation. He has a deep understanding of medicines, compliance, and patient safety, ensuring onlinemeds operates to the highest standards while providing safe and accessible care.